Study Raises Alarm as New Health Issues Linked to Covid Shots

A new study has raised serious concerns for the safety of the vaccinated population as new health issues have been linked to Covid mRNA shots.

The research was published in December 2023 by the renowned peer-reviewed Nature Journal.

Accoridn got the study’s paper, the mRNA injections trigger suffer high rates of ribosomal “frameshifting.”

The issue causes recipients’ cells to produce off-target proteins that can trigger unintended immune reactions.

Off-target cellular immune responses occur in 25% to 30% of people who have received the Covid shot, according to the researchers.

The news comes as the U.S. Food and Drug Administration (FDA) and Australia’s Therapeutic Goods Administration (TGA) are still refusing to release the RNA stability data.

The government health agencies supposedly relied on the data when approving a change to Pfizer’s shot that allowed it to be transported and stored at temperatures of -20 degrees Celsius instead of -70 C.

The FDA also authorized Pfizer to swap the phosphate-buffered saline buffer used in the adult formulations, to a tromethamine (Tris) buffer in the version of the shots used on children.

FDA did not require any kind of testing to be conducted, however.

No data has been released in support of its decision to allow the swap and federal health agency are digging their heels in over making the information public.

According to recently published research, the nanolipid in Comirnaty, made by Pfizer/BioNTech, is toxic to cells.

It triggers proinflammatory cytokines and reactive oxygen species that can disrupt the mitochondrial membrane causing it to release its content, cause RNA mistranslation, DNA mutations, destruction of the nuclear membrane, and more, the study found.

Frequent repetitions of Covid “booster” injections and/or using mRNA in other vaccines poses a grave public health risk, the scientists warn.

As explained in that paper:

A key feature of therapeutic IVT [in vitro-transcribed] mRNAs is that they contain modified ribonucleotides, which have been shown to decrease innate immunogenicity and can additionally increase mRNA stability, both of which are favorable characteristics for mRNA therapies …

Pseudouridine (Ψ) is known to increase misreading of mRNA stop codons in eukaryotes, and can affect misreading during prokaryotic mRNA translation. 1-methylΨ does not seem to affect codon misreading, but has been shown to affect protein synthesis rates and ribosome density on mRNAs, suggesting a direct effect on mRNA translation …

Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.

The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling during IVT mRNA translation, with frameshifting occurring at ribosome slippery sequences …

[T]hese data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.

Ribosomes are responsible for reading the code from RNA.

The inclusion of synthetic methyl pseudouridine causes the ribosomes to misread the RNA’s instructions.

RNA code consists of groups of three bases (codons) that must be read in the correct order for a desired protein to be created.

Because the methyl pseudouridine is not a perfect fit, it causes the decoding process to stall and shift – hence the term “+1 ribosomal frameshifting”.

There’s basically a stutter in the decoding process, as your cells don’t understand what’s being asked for.

This stuttering causes the decoding to skip a letter, thereby garbling the entire code.

As a result, unintended “nonsensical” proteins are produced instead of the desired SARS-CoV-2 spike.

That, in turn, means that your immune system will not produce antibodies against SARS-CoV-2, but rather against these aberrant proteins.

According to the authors, off-target cellular immune responses occur in 25% to 30% of people who have received the Covid mRNA injections.

This issue was noted by molecular virologist David Speicher Ph.D.:

Whenever our cells create an abundance of unintended proteins or prevent production of appropriate proteins it could lead to an unintended immune response with a huge potential to cause harm.

However, not knowing exactly what proteins are being produced is far from the only problem with these gene-based shots.

As reported by investigative journalist Maryanne Demasi, Ph.D., the U.S. FDA and Australia’s TGA both refuse to release the RNA stability data they supposedly relied on when approving a change to Pfizer’s shot.

Pfizer has also refused, without explanation, to disclose the same data.

Demasi writes:

… when the FDA granted authorization in December 2020, it specified the vaccine had to be stored between -80ºC and -60ºC, requiring special ultra-cold freezers, which proved challenging to areas with limited resources.

But by February 2021, Pfizer had apparently solved the problem.

It submitted new ‘RNA stability data’ to the FDA demonstrating the vaccine could be stored in conventional freezers (-20ºC) and no longer required ultra-cold freezers.

The FDA approved the change swiftly.

Two months later, Australia’s Therapeutic Goods Administration (TGA) also approved Pfizer’s application, allowing unopened vials to be stored at -20ºC for up to 2 weeks.

Storage temperature wasn’t the only change.

Drug regulators also approved extensions to the vaccines’ expiry dates.

Various batches of Pfizer’s vaccine, for example, had their expiry dates extended by one year (FDA) or 6 months (TGA).

But given the sensitivity of RNA to changes in temperature and storage duration, what stability data did the regulators rely on to green-light these decisions?

As it stands, we have no idea, and that’s a problem.

Phillip Altman, who has more than four decades of experience in clinical trials and regulatory affairs, also weighed in on the issue.

“It’s critically important to know about the stability of RNA in the vaccines because if the RNA disintegrates, then the efficacy of the vaccine goes down,” Altman told Demasi.

Altman is also concerned about safety because data reveal some shots contain far higher doses of mRNA than others.

The leading expert notes that such “hot lots” are associated with more adverse events and deaths. 

Mounting research shows the shots do not contain “nothing but intact RNA.”

They also contain fragments of RNA, as well as DNA contamination, both of which can have deleterious health effects.

Demasi quotes David Wiseman, Ph.D., a research bioscientist involved in medical product development, who told her:

We need to know about the bits of RNA that are not intact.

It’s possible that small fragments of mRNA also have biological effects such as inflammation or controlling how other RNA works.

The safety of the nanolipid used to encase the mRNA in the shots is also being questioned.

Independent researcher Gabriele Segalla, an Italian biochemist who specializes in the chemistry of microemulsions and colloidal systems, recently discussed his findings.

His research was presented in two peer-reviewed reports published in the International Journal of Vaccine Theory, Practice and Research (IJVTPR).

The first, published in late January 2023, titled “Chemical-Physical Criticality and Toxicological Potential of Lipid Nanomaterials Contained in a COVID-19 mRNA Vaccine,” details the toxic potential of the nanolipid in Comirnaty, made by Pfizer/BioNTech.

Importantly, this paper highlights the potential for reactive oxygen species (ROS) formation in various organs, including the kidneys, liver, heart, and brain.

According to this paper:

Of particular concern is the presence in the formulation of the two functional excipients, ALC-0315 and ALC-0159, never used before in a medicinal product, nor registered in the European Pharmacopoeia, nor in the European C&L inventory.

The current Safety Data Sheets of the manufacturer are omissive and non-compliant, especially with regard to the provisions of current European regulations on the registration, evaluation, authorization and restriction of nanomaterials.

The presence of electrolytes in the preparation and the subsequent dilution phase after thawing and before inoculation raise well-founded concerns about the precarious stability of the resulting suspension and the Polydispersity index of the nanomaterials contained in it, factors that can be hypothesized as the root causes of numerous post-vaccination adverse effects recorded at statistical-epidemiological level.

The second paper, “Apparent Cytotoxicity and Intrinsic Cytotoxicity of Lipid Nanomaterials Contained in a COVID-19 mRNA Vaccine,” published in mid-October 2023, focuses on the nanolipid ALC-0315.

The nanolipid in Comirnaty is toxic to cells and triggers pro-inflammatory cytokines and reactive oxygen species that can disrupt the mitochondrial membrane causing it to release its content, cause RNA mistranslation, DNA mutations, destruction of the nuclear membrane, and more.

It describes how ALC-0315 — one of the molecules used to create Comirnaty’s nanoparticle delivery system — forms “proinflammatory cytokines and ROS that can disrupt the mitochondrial membrane and release its content, cause RNA mistranslation, polymerization of proteins and DNA, DNA mutations, destruction of the nuclear membrane and consequent release of its content.”

“Thus, the prospect of frequently repeated COVID ‘booster shots,’ and also that of extending mRNA technology to vaccines against other pathogens or non-infectious diseases, conjures up a very grave public health risk,” he writes.

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