Experts are raising the alarm over concerns about the rapid increase in the number of vaccinated people now suffering from Vaccine-Acquired Immune Deficiency Syndrome (VAIDS).
A new study from the world-renowned Cambridge University in England has found that there may be around a 1 in 10 chance that Pfizer’s mRNA COVID-19 vaccines will not generate spike proteins but something else.
The Cambridge researchers warn that a large number of those injected with the Pfizer shots may have suffered a negative autoimmune response.
The study authors found that 8 percent of the time, Pfizer’s mRNA Covid shots are mistranslated.
This mistranslation of the mRNA leads to the formation of unintended proteins.
“Our work presents both a concern and a solution for this new type of medicine,” said leading author Anne Willis in the study’s press release.
The vaccines work by using mRNA as a set of instructions for the body.
The mRNA is supposed to trigger a response from the body to develop spike proteins to fight off the virus.
Once the vaccine enters the cell, ribosomes interpret the mRNA instructions to make proteins, like spike proteins.
Yet, if the instructions are misinterpreted, errors in the final protein may be produced.
Some errors are minor, like misspelling one word in a text.
However, some errors are more detrimental.
In some cases, these errors can lead to a breakdown in the body’s immune system similar to the effects of acquired immunodeficiency syndrome (AIDS).
This misinterpretation is called a frameshift, which occurs when one or two mRNA bases are skipped.
Since mRNA bases are translated in sets of threes, skipping a base would affect all the sequences downstream, leading to new proteins being formed.
While most naturally occurring mRNA contains uridine, the Pfizer mRNA vaccines use N1-methyl pseudouridine.
This makes the mRNA sequence hardier and less prone to breakdown by the immune system.
Pfizer’s opting for less commonly occurring mRNA bases is also why some scientists call the mRNA vaccines “modified RNA,” or “modRNA.”
By implementing additional edits to the mRNA sequences, the authors were able to reduce further frameshifted proteins.
“For future use of mRNA technology, it is important that mRNA sequence design is modified” to reduce these shifts, the authors of the study concluded.
Apart from frameshift errors, the N1-methyl pseudouridine modification can also slow down and interrupt mRNA translation to protein.
This can potentially lead to shorter-than-expected protein sequences.
“Under ideal circumstances, ribosomes translate the vaccine mRNA into the S [spike] protein,” Dr. Adonis Sfera, assistant clinical professor of medicine at Loma Linda University, said in response to the Cambridge study.
“If the cellular machine (ribosomes) ‘detect’ the difference [between normal uridine and N1-methylpseudouridine], it can result in stalling or mistranslation.”
In the study, published in the peer-reviewed Nature Journal, the researchers first inoculated mice with both Pfizer and AstraZeneca vaccines.
They found that Pfizer vaccines were significantly more likely to produce frameshifted proteins.
Researchers then compared vaccine inoculations in humans.
They compared 21 participants who took the Pfizer vaccine to 20 who took the AstraZeneca vaccine.
None of the AstraZeneca vaccinees had an immune reaction to proteins made from mistakes in translation.
However, around one-third of the Pfizer vaccinees did.
The authors wrote that none of the Pfizer vaccinees developed adverse effects during the study.
Nevertheless, they raised the alarm about the long-term health impact and warned that they are concerned about immunological consequences.
“Mis-directed immunity has huge potential to be harmful,” immunologist Dr. James Thaventhiran, one of the study’s lead authors, said in the press release.
“Off-target immune responses should always be avoided.”
The authors did not further define misdirected immunity in their study.
Generally, misdirected immunity describes a reaction where the body’s immune system targets the wrong thing.
In this case, it can mean that rather than training the body to fight spike protein, it is trained to fight unnaturally occurring proteins instead.
This was highlighted by Norwegian nutritional biologist Marit Kolby in her post on Twitter/X.
It induces frameshift mutations, increasing the likelihood of an aberrant protein that the immune system is trained to react to
— Raphael Sirtoli (@raphaels7) December 12, 2023
Additionally, some health experts are concerned that these unique proteins may increase a person’s risk of developing autoimmune disorders.
Molecular biologist professor Vladimir Uversky, PhD, from the University of South Florida and physician Dr. Alberto Rubio-Casillas concluded that VAIDS may occur if immune cells start attacking cells producing these aberrant proteins.
“A mistranslated protein can [also] resemble a human protein and trigger antibody formation,” Dr. Sfera added.
Autoimmunity occurs when the immune system attacks self-tissues.
It can occur for many years before symptoms manifest.
Study findings by immunologist Aristo Vojdani suggest that spike proteins have the potential to cause cross-reactions with over 20 different human tissues.
The cross-reactions mean the body accidentally targets self-tissue in a fight against other pathogens.
This reaction essentially caused the body to destroy itself.
The production of these aberrant proteins and peptides may also increase a person’s risk of cancer, Mr. Uversky and Dr. Rubio-Casillas are warning.
Melanoma cells have been shown to induce frameshifted proteins to escape immune detection.
“In our opinion, there is a possibility that during the translation of mRNA from COVID-19 vaccines, the aberrant proteins generated during frameshifting could activate survival mechanisms mimicking those developed by cancer cells to escape immune surveillance,” the two stated.
Researchers currently do not know the structure or sequence of the new proteins formed.
The authors identified in the study that one of the proteins detected was a chimeric protein—one formed by joining two or more genes that originally coded for separate proteins.
The chimeric protein was structurally similar to human proteins, which might induce autoimmune responses.
“Of course, nobody knows for sure that the observations are linked to harms, but the fact they theoretically might be, and that regulators seem disinterested in investigating such a possibility, should be of huge concern to all,” Dr. Jonathan Engler, co-chair of the Health Advisory and Recovery Team (HART) said of the findings.
HART is a UK group of academic experts sharing concerns about COVID-19-related recommendations.
“It should be emphasized that the … paper was submitted for publication nearly a year ago, and presumably, the work was carried out some months before then,” he added.
“Moreover, the investigators weren’t some third-rate-university, part-time academics.”